Awards and Fellowships
- Awarded Ramanujan Fellowship from Department of Science and Technology, Government of India (July 2010-).
- Awarded Kishimoto Foundation Fellowship from WPI Immunology Frontier Research Center, Osaka University (April 2010-June 2010).
- Awarded Japan Society for the Promotion of Science (JSPS) Post-doctoral Fellowship from Government of Japan (April 2008-March 2010).
- Awarded Japanese Government Scholarship (MEXT) from Government of Japan (April 2003-March 2008) for pursuing doctoral thesis.
Associate Professor (August 2016-till date), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
Assistant Professor (July 2010-July 2016), Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
Adjunct Associate Professor. (March 2010-till date),World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
JSPS Post-doctoral Fellow (April 2008-March 2010), Laboratory of Host Defense, World Premier International Research Center (WPI), Immunology Frontier Research Center, Osaka University, Japan.
Ph.D.[April 2004-March 2008 as Japanese Government Fellow (MEXT Fellow)], Immunobiology, Graduate School of Medicine, Osaka University, Japan with Professor. Shizuo Akira.
Innate immunity is first line of defense system and promptly activated after microbial infection to initiate protective responses through production of inflammatory cytokines from various immune cells. Innate immune system consists of humoral components such as complements, acute phase proteins and cellular components such as Monocytes, Macrophages, Dendritic cells, Eosinophils, Basophils, Neutrophils, Mast cells and Natural-killer cells. The humoral components have a broad range of actions against microorganisms, including gram-positive and gram-negative bacteria, fungi and viruses. The cellular components either directly kill the microbial pathogens through phagocytosis or induce production of cytokines, which helps in the elimination of pathogens. The innate immune cells express various pattern recognition receptors (PRRs) which recognize signature molecules of the pathogen. These signature molecules are essential for the survival of the pathogen and known as a pathogen associated molecular pattern (PAMPs). These PRRs recognizes different PAMPs of the pathogen in various compartments of the cells and trigger induction of inflammatory cytokines for the host defense. Furthermore, the innate immune responses are also required for the development of the pathogen specific adaptive immunity through B and T lymphocytes.
The aims of our group are:
To identify new innate receptors or adaptor or signaling molecules through various screening systems and characterize the identified genes in vitro and in vivo.
To integrate the basic knowledge of innate immune signaling pathways to the susceptibility with human infectious disease.
To study the cross-talk and diverse regulation of various innate signaling pathways.
To integrate the basic knowledge of PAMPs, PRRs and innate immune signaling pathways in development of ideal vaccine adjuvant.
Kumar H* and Bot A, Innate immune recognition mechanism and Translational Opportunities, an Editorial for special issue entitled. Innate Immunity: Basic science and translational update., International Reviews in Immunology, 2013 Apr;32(2):113-5. (*corresponding author).
Kumar H, Takeuchi O. and Akira S. (2013) Toll-Like Receptors. In: Lennarz W.J. and Lane M.D. (eds.) The Encyclopedia of Biological Chemistry, vol. 4, pp. 396-401. Waltham, MA: Academic Press.
Kumar H*, Kawai T, Akira S, Pathogen Recognition by Innate Immunity, International Reviews in Immunology, 2011 Feb; 30(1): 16-34 (*corresponding author). [This article is top "Most cited article", "Most read article" and therefore interviewed by Editor in Chief of the Journal] Click Here
Kumar S, Ingle H, Prasad DVR, Kumar H*, Recognition of Bacterial Infection by Innate Immune Sensors, Critical Reviews in Microbiology, 2013, 2013 Aug;39(3):229-46. doi: 10.3109/1040841X.2012.706249. (*corresponding author). [This article is highlighted in the latest news and it is top "Most read article" of the Journal] Click Here
- Kumar S, Ingle H, Mishra S, Mala RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H*. IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependnt and independent anticancer activity. Cell Death & Disease, 2015 (Accepted). (*corresponding author).
- Kumari P, Narayanan S, Kumar H*. Herpes viruses: Interfering innate immunity by targeting viral sensing and interferon pathways. Reviews in Medical Virology, 2015, DOI: 10.1002/rmv.1836. (*corresponding author).
- Bharti D, Kumar A, Mala RS, Kumar S, Ingle H, Shankar H, Joshi B, Raut AA, Kumar H*, The role of TLR9 polymorphism in susceptibility to pulmonary tuberculosis., Immunogenetics, 2014, 66, 675-681. (*corresponding author).
- Nagi RS, Bhat AS, Kumar H* Cancer: A Tale of Aberrant PRR Response. Frontiers in Immunology, 2014 Apr 9;5:161. doi: 10.3389/fimmu.2014.00161. (*corresponding author).
- Mala RS, Reddy MC, Prasad DVR, Kumar H*. Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology, Frontiers in Immunology, 2013, DOI: 10.3389/fimmu.2013.00248. (*corresponding author).
- Lee PY, Kumagai Y, Li Y, Takeuchi O, Yoshida H, Weinstein J, Kellner ES, Nacionales D, Barker T, Kelly-Scumpia K, Rooijen N, Kumar H, Kawai T, Satoh M, Akira S, Reeves WH, TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. Journal of Experimental Medicine2008, Dec 22; 205(13): 2995-3006.
- Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S, Cutting Edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-alpha production in plasmacytoid dendritic cells.Journal of Immunology (Cutting Edge Section) 2009 Apr 1;182(7):3960-3964.
- Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S, Poly I:C-induced activation of NK cells by CD8alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. Journal of Immunology 2009 Aug 15;183(4):2522-2528.
- Kumar H, Kawai T, Akira S, Pathogen Recognition in the Innate Immune response. Biochemical Journal 2009 Apr 28;420(1):1-16.
- Kumar H, Kawai T, Akira S, Toll-like receptors and natural immunity, Biochemical and Biophysical Research Communications2009 Oct 30;388(4):621-625.
- Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T, Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan, Journal of Immunology 2009 Dec 15;183(12):8061-8067.
- Tsuchida T, Zou J, Saitoh T, Kumar H, , Abe T, Matsuura Y, Kawai T, Akira S, The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular, Immunity 2010 Nov 24;33(5):765-76.
- Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, Kawai T, NLRC5 deficiency does not influence cytokine induction by virus and bacteria, Journal of Immunology2011 Jan 15;186(2):994-1000.
- Kim YG, Park JH, Remier T, Kawai T, Kumar H, Akira S, Wobus C, Nunez G, TLR and Nod1/2 Signaling Augmented by Norovirus or Poly I:C Mediate Bacteria-Induced Lethality in Mice, Cell Host and Microbe2011 Jun 16;9(6):496-507.
- Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nature Immunology. 2005 Oct;6(10):981-988.
- Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-stranded RNA. Journal of Immunology. (Cutting Edge Section) 2006 Apr 15; 176(8):4520-4524.
- Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses. Journal of Experimental Medicine 2006 Jul 10; 203(7):1795-1803.
- Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S. VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition. Journal of Biological Chemistry 2006 Dec 1;281(48):36897-36904.
- Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, Echo DV, Fitzgerald KA, Young HA, Ching LM, and Vogel SN. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis. Journal of Experimental Medicine 2007 Jul 9;204(7):1559-1569.
- Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Kawai T, Akira S.Alveolar macrophages are primary interferon-αlpha producer in response to lung RNA virus infection. Immunity 2007 Aug:27(2):240-252.
- Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S. Enhanced TLR-mediated NF-IL6-Dependent Gene Expression by Trib1 Deficiency. Journal of Experimental Medicine2007 Sep 3;204(9):2233-2239.
- Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S.Differential role of TLR- and RLR-signaling in innate and adaptive immune response to influenza A virus infection and vaccination. Journal of Immunology2007 Oct 1;179(7):4711-4720.
- Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces cytotoxic T cell response via MyD88. Journal of Virology 2008, 82(1): 196-206.
- Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S. Cutting Edge: Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. Journal of Immunology (Cutting Edge Section) 2008, Jan 15; 180(2) 683-687.
- Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. Tank-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature2008, Feb 7; 451 725-729.
- Kumar H, Malhotra D, Goswami S, Bamezai R. How far have we reached in tuberculosis vaccine development? Critical Reviews in Microbiology. 2003;29 (4):297-312.
- Kumar H, Takeda K, Akira S (2004) Toll-like Receptors, Encyclopedia of Biological Chemistry (W.J. Lennarz & M.D. Lane, eds), Elsevier publication, Oxford, Vol.4, pp. 190-194.
- Malhotra D, Darvishi K, Lohra M, Kumar H, Grover C, Sood S, Reddy BSN, Bamezai R. Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population. European Journal of Human Genetics 2006 Apr; 14(4):438-442.
Publications from IISER, Bhopal
Publications during post-doctoral training:
Publications during doctoral training:
Publications before doctoral training:
- Harshad Ingle
- Sushil Kumar